SP108A SINGLE CENTRE EXPERIENCE ON HIGH CUT-OFF HAEMODIALYSIS FOR TREATMENT OF MYELOMA CAST NEPHROPATHY
نویسندگان
چکیده
منابع مشابه
High cut-off dialyser haemodialysis in cast nephropathy
Sir, The importance of renal function in the prognosis of patients with multiple myeloma (MM) has been well established and rapid reversal of renal failure may offer the best long-term outcome. The use of extracorporeal means of removing immunoglobulin free light chains (FLCs) responsible for cast nephropathy in patients with MM is controversial. Nephrologists are interested in a treatment stra...
متن کاملSuccessful use of combined high cut-off haemodialysis and bortezomib for acute kidney injury associated with myeloma cast nephropathy.
We present the case of a 58-year old female with de novo dialysis-dependent acute kidney injury (AKI) secondary to myeloma cast nephropathy. The patient underwent extended high cut-off haemodialysis (HCO-HD), in conjunction with bortezomib-based chemotherapy, and soon became dialysis independent with normal renal function. To our knowledge, this is the first time this treatment strategy has bee...
متن کاملCast nephropathy with acute renal failure treated with high cut-off haemodialysis in a patient with multiple myeloma.
We report a case of a Chinese woman who presented with multiple myeloma and acute renal failure due to cast nephropathy, with an extremely high serum lambda free light chain concentration. She was successfully treated with chemotherapy and high cut-off extended haemodialysis. High cut-off haemodialysis is a new treatment modality which can achieve rapid free light chain clearance. This may cont...
متن کاملMultiple myeloma and high cut-off haemodialysis: On the right track for better outcomes?
Background: Acute kidney injury secondary to cast nephropathy is a common complication of multiple myeloma. Extracorporeal light chain elimination by high cut-off haemodialysis has been described as an adjuvant to effective chemotherapy to limit free light chain toxicity. The purpose of this study was to evaluate the impact of high cut-off haemodialysis and bortezomib-based chemotherapy on rena...
متن کاملComment on "Haemodialysis using high cut-off dialysers for treating acute renal failure in multiple myeloma".
INTRODUCTION Acute renal failure (ARF) occurs in 12%-20% of all multiple myeloma (MM) cases, and the survival of these patients depends on renal function recovery. Renal function is not recovered in 75% of dialysis-dependent patients, and their mean survival with replacement therapy is less than one year. Renal tubular disease is the most frequent cause of renal failure. It is present in more t...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2019
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfz103.sp108